“Like trying to mix oil and water, most people assume that science and spirituality don’t play well together,” psychopharmacologist Roland Griffiths said in a 2016 TEDMED talk. “But it’s not true.” Welcome to the psychedelic renaissance. After decades as a hush-hush pastime, hallucinogens (think: magic mushrooms, LSD, and MDMA) are finally getting their moment in the limelight thanks to their powerful potential to address hard-to-treat ailments ranging from anxiety to addiction and beyond—and, now, there’s the medical research to back it up. Check out what scientists and seekers are saying about psychedelics and their enormous healing possibilities.