LSD (lysergic acid diethylamide), also commonly known as acid, is a psychedelic drug that gained popularity in the 1960s as part of the counterculture revolution. Originally created in 1938 by Albert Hofmann from lysergic acid, which is found in the ergot fungus, LSD was researched as a potential psychotherapeutic medication in the 1950s and 1960s until it was classified as a controlled substance in the 1970s and all research was discontinued. There has been renewed interest in the use of the drug as part of treatment for depression, anxiety, and addiction, and much research is currently being devoted to documenting its clinical effects. The effects of a good LSD “trip” commonly include feelings of euphoria, visual or auditory hallucinations, and a sense of connectedness to the universe; a bad trip can include feelings of anxiety, paranoia, irrational fears, and other distressing emotional states. It is currently illegal to possess or ingest LSD for recreational purposes.

Interview with Albert Hofmann, the Man Who First Synthesized LSD

The late chemist Albert Hofmann discussed his psychedelic research on LSD in the July, 1976 issue of High Times.

The Trip Treatment

Research into psychedelics, shut down for decades, is now yielding exciting results.

Microdosing’s Micromoment

Consuming crumb-size amounts of psychedelics — not to get high but to feel more focused and creative and present — has moved a tiny bit mainstream.

LSD Changes Something About The Way You Perceive Time

The perception of time is a fundamental process of the brain, linked tightly to attention, emotions, memory, psychiatric and neurological disorders, and even consciousness—but while scientists have been anecdotally noting how drugs can change time perception for decades, very few have been able to...

My Adventures with the Trip Doctors

My first psilocybin journey began around an altar in the middle of a second-story loft in a suburb of a small city on the Eastern Seaboard.

Tripping in LSD's Birthplace: A Story for "Bicycle Day"

After consuming magic mushrooms in Basel, Switzerland, I ran into Albert Hofmann, the chemist who catalyzed the psychedelic era.

The Struggle to Turn Psychedelics into Life-Changing Treatments

Scientist Robin Carhart-Harris wants to use psychedelic drugs to treat psychiatric disorders. Early results are promising—but can he convince big pharma and the public of their potential?

Psychedelics Could Trigger a ‘Paradigm Shift’ in Mental Health Care

A new review of studies finds that LSD, psilocybin, and MDMA hold potential for treating mental illness.

‘Microdosers’ of LSD and magic mushrooms are wiser and more creative

We just ran the first ever pre-registered scientific study on the microdosing of psychedelics and found some very promising results.

Here’s Everything to Know About Microdosing—Including How to Safely Do It

According to a 2019 survey-based study published in the Harm Reduction Journal, researchers found that microdosers experience a number of emotional, physical, and cognitive benefits.


Psychedelic Research